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1 April 1994 EXPERIMENTAL BORRELIA BURGDORFERI INFECTION IN PEROMYSCUS LEUCOPUS
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Abstract

We evaluated the susceptibility of laboratory reared adult and infant white-footed mice (Peromyscus leucopus) to a known pathogenic isolate of Borrelia burgdorferi (N40). Two-month-old and 3-day-old Peromyscus were inoculated intradermally with 106 to 107 spirochetes. At 21 days for adults or 30 days for infants post inoculation, mice were killed, and tissues were cultured for spirochetes and examined microscopically. Based on serology and culture, adult mice became infected but did not have any gross or microscopic lesions. Mice inoculated as infants became infected, and also developed carditis and multifocal arthritis. Contact transmission between inoculated infants and their naive mothers was not observed. Age at inoculation appeared to be a critical factor in inducing Lyme borreliosis lesions in Peromyscus leucopus, as in other species.

Moody, Terwilliger, Hansen, and Barthold: EXPERIMENTAL BORRELIA BURGDORFERI INFECTION IN PEROMYSCUS LEUCOPUS
Kathleen D. Moody, Gordon A. Terwilliger, George M. Hansen, and Stephen W. Barthold "EXPERIMENTAL BORRELIA BURGDORFERI INFECTION IN PEROMYSCUS LEUCOPUS," Journal of Wildlife Diseases 30(2), 155-161, (1 April 1994). https://doi.org/10.7589/0090-3558-30.2.155
Received: 1 June 1993; Published: 1 April 1994
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