Prevalence of larval nematodes (Physocephalus sp., Spirurida, Spirocercidae) and associated cysts are reported from the blue spiny lizard, Sceloporus serrifer, from Texas (USA). Prevalence of infection was 29%, with seven of 24 animals infected. Larvae were found in gastric submucosal and occasionally mucosal cysts with a mean (±SE) of 287 ± 9.04 μm in diameter. The nematodes evoked a chronic granulomatous response including cyst formation with focal destruction of gastric glands. Cysts resolved into areas of fibrosis. Sceloporus serrifer is a new host record for Physocephalus sp.