An adult hybrid orangutan (Pongo abelii/pygmaeus) was presented to a veterinary teaching hospital for laparoscopic tubal ligation. The orangutan was immobilized with the use of injectable anesthetic agents, then orotracheally intubated. Anesthesia was maintained with the use of isoflurane in oxygen, and positive-pressure ventilation was used to ensure adequate gas exchange. Parameters monitored included arterial blood pressure, ECG, capnometry, and arterial blood gases. Anesthesia was uneventful, and recovery was smooth.