Human–wildlife interfaces are increasing rapidly due to the disproportionate growth of human and wildlife populations in a spatial context. The Himalayan system, a global biodiversity hotspot, is subject to landscape modification from various anthropogenic activities. In this study, we offer insights into the human–wildlife interface, reflecting avoidance or coexistence, with implications for local and landscape management strategies. We investigated fine-scale space use and temporal activity patterns of mammalian wildlife in a human-dominated landscape, outside a protected area. The research methods involved robust digital camera trap sampling (n = 131) across the target area (116 km²) with a total human population of 153,585. We developed a new sampling strategy that accounted for spatial heterogeneity in the habitats and variations in mammalian community composition. Our results showed that, in spite of high usage and the presence of humans across the study area, 16 wild mammal species used the area with varying intensities, exploiting habitat and forage availability. Of the camera traps placed in the study area, 70.23% had overlapping captures for humans on foot and wild mammal species. Generalist species used natural, modified, and altered habitats, while herbivores remained in natural and modified areas. However, some mammals that used modified/altered areas avoided humans by modifying their temporal activity. In the context of management of large landscapes, including areas outside the protected area network, the results of this study highlight the significant plasticity exhibited by wild mammals in negotiating natural and human-modified habitats. This offers an opportunity to develop conservation management strategies focusing on these fine-scale patterns and human actions.