Hedyotis cheniana R. J. Wang and H. wuzhishanensis R. J. Wang, from Hainan Province, China, are described as new. Hedyotis cheniana is similar to H. terminaliflora Merrill & Chun in having a terminal condensed inflorescence, but differs in having elliptic to ovate, or sometimes circular leaves with rounded or truncated leaf bases and distinct petioles, narrowly triangular stipules with a lacerate margin, heterostylous flowers, and short calyx tubes. Hedyotis wuzhishanensis is similar to H. paridifolia Dunn in having two pairs of leaves that are closely adjacent to the terminal inflorescence, but it can be distinguished by its covering of sparse to dense hairs on all vegetative organs, four to five pairs of secondary veins, and distinct petioles. These two new species belong to Hedyotis sect. Diplophragma Wight & Arnott based on the dehiscent pattern of their mature capsules.