A new monotypic genus of Loranthaceae, Pusillanthus Kuijt, is described and illustrated from Venezuela, based on Phthirusa trichodes Rizzini. It contrasts with other genera of small-flowered Neotropical Loranthaceae in combining an umbellate capitulum, tetramery, bisexual flowers with nearly sessile anthers, the absence of epicortical roots, and the presence of a conspicuous indument. The other genera have racemic or spike-like inflorescences (rarely solitary, axillary flowers). Species in the genus Struthanthus may represent the closest relatives, differing in their versatile anthers, 6-merous flowers, epicortical roots, and (except a single, unrelated Bolivian species) lack of indument; however, that genus is believed to be paraphyletic.