In this article, a guide is presented to help biology teachers so that they can process the subject of the eye and eye defects with an interdisciplinary approach. The guide, which was created by considering the stages of a lesson plan, includes content information, suggestions, and various directions that can help the teacher at every stage. The presented content is arranged to guide students from time to time to remind them of some concepts and subjects they learned in physics lessons while processing the structure of the eye and eye defects. In this way, it is aimed that the students can perceive the information they learned in physics and biology lessons holistically and see the relationships and connections more easily. Thus, it is thought that this situation will also benefit their meaningful learning and the permanence of knowledge.