Vinegaroons are members of a guild of apex arthropod predators in the high desert grasslands of southeastern Arizona. Despite their importance as major predators in the ecosystem, almost nothing is known about their potential prey, predators, or competitors. We evaluated predator-prey relationships of vinegaroons and 30 species of potential prey, 27 species of potential predators, and the detailed interactions among three taxa of their apex predator guild. With few exceptions, vinegaroons overpowered and preyed on most potential prey within a suitable size range, were almost immune to predation, and appeared to be the dominant species in interactions with other predator guild members. Their most vulnerable life stages were the first two free-living instar stages, whereas adults and fourth instar individuals were not preyed on by any predators active in the same areas and times as vinegaroons. Third instar individuals were a crucial transition stage in which they had a few predators but also were large enough that they required capturing many prey items to grow sufficiently to molt to the fourth instar. In interactions among arthropod predators, the general observation was that when predation occurred, the larger individual usually prevailed irrespective of taxon. Cannibalism among adult and fourth instar vinegaroons does not occur under natural conditions in contrast to when they are placed together in artificial stressful situations. Cannibalism of the three smallest instars appears likely and might partially explain why they are solitary and spend minimal time foraging.