The cyst wall of the parasitic protozoan, Giardia intestinalis, is composed of a polymer of N-acetylgalactosamine, the precursor of which is synthesized by an inducible enzyme pathway. The first enzyme in this pathway, glucosamine 6-phosphate isomerase, is transcriptionally regulated. During encystment and in mature cysts this isomerase appears to be modified by ubiquitin attachment. Thus, it might be targeted for destruction by an ubiquitin-mediated pathway, suggesting that glucosamine 6-phosphate isomerase expression is tightly regulated.
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1 March 2002
Giardia intestinalis Glucosamine 6-Phosphate Isomerase: the Key Enzyme to Encystment Appears to be Controlled by Ubiquitin Attachment
ALEX B. LOPEZ,
MOHAMMED T. HOSSAIN,
HARRY VAN KEULEN
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The Journal of Eukaryotic Microbiology
Vol. 49 • No. 2
March 2002
Vol. 49 • No. 2
March 2002
Competition inhibition
cyst wall
encystment
excystation
fusion protein
glutathione transferase
ubiquitin