The microbicidal effect of a monoclonal antiidiotypic antibody, mimicking the activity of a yeast killer toxin, characterized by a wide antimicrobial spectrum, has been evaluated in vitro against two relevant species of protozoan parasites, Leishmania major and Leishmania infantum. The antiidiotypic antibody exerted a significant and dose-dependent antileishmanial activity against parasite promastigotes in comparison to an irrelevant isotype-matched monoclonal antibody. This is the first demonstration that an antibody, which had been already shown to be fungicidal and bactericidal, may also exert a direct microbicidal activity against protozoa.
How to translate text using browser tools
1 July 2002
In Vitro Leishmanicidal Activity of a Monoclonal Antibody mimicking a Yeast Killer Toxin
DIANELLA SAVOIA,
CLAUDIO AVANZINI,
STEFANIA CONTI,
VALTER MAGLIANI,
RAFFAELE FRAZZI,
LUCIANO POLONELLI
ACCESS THE FULL ARTICLE
It is not available for individual sale.
This article is only available to subscribers.
It is not available for individual sale.
It is not available for individual sale.
The Journal of Eukaryotic Microbiology
Vol. 49 • No. 4
July 2002
Vol. 49 • No. 4
July 2002
Antibiotic activity
killer antibodies
Leishmania infantum
Leishmania major