The genus Meuffelsia Grichanov, gen. n. is described from South Africa to accommodate two new species, M. erasmusorum Grichanov. sp. n. and M. manningi Grichanov, sp. n. The new genus has been placed in the subfamily Peloropeodinae, and is considered close to the genera Micromorphus and Peloropeodes. Brief information on the habitat of M. erasmusorum is provided; in general, representatives of the new genus seem to prefer mesic riparian environments. A key to Afrotropical peloropeodine and allied genera of long-legged flies is compiled, and characters of the new genus are discussed.