This study was conducted to evaluate the effect of Enterococcus faecium (EF) and endo-1,4-β-xylanase (XY) in finishing pigs. The pigs were randomly divided into four treatments with eight replications per treatment and four pigs per pen in a 2 × 2 factorial arrangement with two levels of EF (0 or 0.1 g kg⁻¹ of feed) and XY (0 or 0.1 g kg⁻¹ of feed). During 0–12 wk, average daily gain and gain to feed ratio (G:F) increased by addition of EF in the diets (P < 0.05). The G:F increased by addition of XY in the diets (P < 0.05). At the 6th week, the results showed that digestibility of dry matter (DM), nitrogen, and energy increased with pigs fed EF supplemented diet compared with diets without EF supplementation (P < 0.05). In addition, administration of XY improved DM digestibility compared with treatments without XY supplementation (P < 0.05). The fecal Escherichia coli and Lactobacillus counts decreased and increased respectively by addition of EF or XY in the diets (P < 0.05). In conclusion, providing finishing pigs with diets that contained EF and XY can improve growth performance, nutrient digestibility, Lactobacillus population, and decrease E. coli counts.