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1 July 2007 Defective Fin Regeneration in Medaka Fish (Oryzias latipes) with Hypothyroidism
Koshin Sekimizu, Masatomo Tagawa, Hiroyuki Takeda
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Wild-type medaka are known to have remarkable capabilities of fin, or epimorphic, regeneration. However, a hypothyroid mutant, kamaitachi (kmi), frequently suffers from injury in fins, suggesting an important role of thyroid hormone in fin regeneration. This led us to examine the relationship between thyroid hormone and fin regeneration using medaka as a model. For this, we first set up a medaka experimental system in which the rate of regeneration was statistically analyzed after caudal fin amputation under normal and hypothyroid conditions. As expected, the regeneration of amputated caudal fins was delayed in hypothyroid kmi –/– mutants. We then examined wild-type medaka with thiourea-induced hypothyroidism to evaluate the requirement of thyroid hormone during epimorphic fin regeneration. The results demonstrate that the growth rate of regenerates was much reduced in severely hypothyroid medaka throughout the regeneration period. This reduction in regenerative rate was recovered by exogenous administration of L-thyroxine. The present study is thus the first to report the direct involvement of thyroid hormone in teleost fin regeneration, and provides a basic framework for future molecular and genetic analyses.

Koshin Sekimizu, Masatomo Tagawa, and Hiroyuki Takeda "Defective Fin Regeneration in Medaka Fish (Oryzias latipes) with Hypothyroidism," Zoological Science 24(7), 693-699, (1 July 2007).
Received: 11 January 2007; Accepted: 1 February 2007; Published: 1 July 2007
epimorphic regeneration
fin regeneration
thyroid hormone
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